Estrogen: To Kill It or To Keep It?
In the bodybuilding and fitness communities, discussions related to anabolic steroid use often tend toward extremism.
Some attempt to completely eliminate estrogen levels in the body, while others allow them to rise unchecked.
The human body always strives to maintain homeostasis.
Homeostasis is the system by which an organism regulates various variables to maintain a stable internal state.
When using anabolic steroids, the hypothalamic-pituitary-testicular axis (HPTA) reacts to the influx of external androgens by trying to reduce endogenous androgen production.
Additionally, aromatizable androgens interact with the aromatase enzyme to increase blood estrogen levels, showcasing the body’s natural mechanism to maintain hormonal balance.
This process can be understood as part of an effort to regulate excessive androgen levels and balance hormones.
The Positive Effects of Estrogen
Like cortisol, estrogen is often misunderstood as a ‘bad’ hormone, but optimal levels of estrogen have various benefits.
Cardiovascular and Cholesterol Management
Estrogen plays a crucial role in cardiovascular health.
Pre-menopausal women have a lower risk of cardiovascular disease, and estrogen therapy is also effective in improving cardiovascular function and cholesterol levels.
One study revealed that using testosterone with an aromatase inhibitor led to a 25% decrease in HDL cholesterol, indicating the detrimental effects of reducing estrogen.
Muscle Growth and IGF-1
Estrogen influences the function of Human Growth Hormone (HGH) and IGF-1, promoting muscle anabolism.
A decrease in estrogen lowers IGF-1 levels and negatively impacts muscle growth.
This phenomenon was also observed with the combined use of testosterone and anti-estrogen drugs.
Sexual Function and Fertility
Estrogen contributes to male libido, fertility, and sperm maturation.
Low estrogen levels lead to a decline in libido and reproductive function, and also negatively affect sperm development.
Preventing Lethargy
In the central nervous system, estrogen regulates serotonin to prevent fatigue and maintain the sleep/wake cycle.
Estrogen deficiency is linked to chronic fatigue, and the use of potent aromatase inhibitors can lead to “steroid fatigue.”
Adequate estrogen levels are essential for healthy physiological function and overall well-being.
When and How Much Should You Lower Estrogen Levels?
How much to lower estrogen levels is not a simple question, but the most accurate way to know is through a blood test.
While using anabolic steroids, you must consult with a doctor and get regular blood tests.
The normal range for estradiol (E2) is defined as 14-55 pg/mL, and it is important to confirm this.
If you cannot get a blood test, you can only gauge estrogen levels by signs and symptoms.
When using an aromatase inhibitor, you must be careful not to lower your estrogen levels too much.
The period of low levels should be minimized, as severely low levels for more than a week can be harmful to your health.
Notably, bodybuilders preparing for a competition use potent aromatase inhibitors, but this is temporary and long-term use can cause discomfort and health risks.
