Cardarine History & Overview
Some performance enhancers are products that enhance performance, while others enhance performance relative to cost.
Sometimes the line between the two can be blurry, but there is no doubt that many people are consistently looking for products that can take their athletic performance to the next level, regardless of cost.
Within that category of supplements, there seems to be none more representative than Cardarine.
Also known by its call sign, GW-501516, Cardarine began with research from two pharmaceutical giants, GlaxoSmithKline and Ligand Pharmaceuticals.
Cardarine is considered a PPAR receptor agonist.
It was initially intended to help with cardiovascular diseases, but during testing, they realized that this drug was actually an amazing endurance supplement.
Individuals who took this supplement showed remarkable improvements in their performance, particularly in cardiovascular exercise.
However, experimental results showed that it caused tumors to develop rapidly in rats at an alarming rate.
While this terrible discovery caused most experiments on this compound to cease immediately, it is important to note that the only finding of cancer causation occurred because mice were administered 500-1000 times+ the amount of Cardarine.
Therefore, while the debate over whether Cardarine is safe or not continues, most people are refraining from using Cardarine.
However, due to its potent ability to enhance endurance, it remains a popular supplement.
Furthermore, it has not yet been determined whether there is a cancer risk even at standard dosages.
Cardarine Functions & Traits
Looking specifically at the chemical interactions of Cardarine, it is a PPAR agonist.
It acts on a group of receptors located at the PPAR receptor site and interacts with the PGC-1a enzyme, as well as interacting with thyroid and steroid hormones that handle gene expression related to energy expenditure, thereby manipulating gene expression.
Simply put, it causes the body to expend energy at ridiculous levels, beyond its normal levels/limits.
Research indicates it can increase fatty acid metabolism in mice.
It can even lower the probability of obesity and help prevent type 2 diabetes, even with a poor diet.
Furthermore, one study showed it increased good cholesterol and decreased bad cholesterol in monkeys, and since these effects seemed to occur regardless of exercise, it is clearly a compound with tremendous potential.
Cardarine Effects
The most noticeable effect is the incredible aerobic performance one can experience when using this compound.
This effect is enhanced for both beginners and advanced users, so virtually anyone taking Cardarine will see a tremendous improvement in their endurance and ability to train longer and harder.
The effects of this compound are so powerful that even individuals taking Trenbolone, a drug notorious for ruining cardiovascular ability, saw tremendous benefits when using Cardarine, and it seems Cardarine can completely negate these negative impacts.
Beyond the incredible performance enhancement effects, Cardarine also offers many benefits for lifestyle.
Its ability to break down body fat, even without significant effort, is one of its biggest advantages.
Extending the data gathered from the aforementioned primate study, individuals can experience remarkable efficacy even while taking Cardarine.
A major plus is that it does not weaken stamina or cause catabolism like other weight loss supplements.
Essentially, it is highly effective at reprogramming how certain metabolic pathways are utilized in the body, allowing you to use more calories for pure energy absorption than anything else.
It also improves nutrient efficiency to a tremendous degree, helping your body better utilize the macronutrients and micronutrients from the food you consume.
Cardarine Side Effects
For the most part, the side effects of Cardarine are not particularly noteworthy unless one considers the cancer risk.
Studies on small rodents showed that Cardarine increased the likelihood of cancer development.
However, it is important to note that the dosages administered in these studies were typically astronomically higher than what is recommended when taking the drug.
Furthermore, there are conflicting study results suggesting that Cardarine use might actually decrease the potential for cancerous tumor formation.
So overall, it’s somewhat confusing as to what the 100% correct answer is regarding the cancer risk question.
However, it is important to note this as a potential side effect.
Beyond that, there are no other side effects.
It does not convert to testosterone or estrogen.
And it possesses no liver toxicity whatsoever, so your organs should remain in good condition.
It also has no impact on testosterone production and does not suppress the HPTA.
Cardarine Administration & Usage
When taking Cardarine, it is recommended to take it orally.
Most research chemical companies sell Cardarine in sublingual dosages that you simply place under your tongue or swallow.
The most effective dosage is approximately 10-15mg for about 8 weeks.
There are also reports suggesting Cardarine should be taken for 12 weeks, and that the dosage should be up to 20mg per dose, not 10-15mg.
As always, prioritize safety by starting with a low dose and gradually increasing it.
Conclusion
Overall, considering cost and effects, this is one of the best supplements an athlete can buy.
It is absolutely amazing in terms of what it can do for the body, but one must always be mindful that cancer risk is one of the side effects, and that the side effects don’t get any more serious than that.
While initial test results from GSK and other major pharmaceutical companies were promising, the fact that they passed on investing in it as a profitable medication due to the risks speaks volumes about how cautious one must be when using this product.
Honestly, unless you are an elite endurance athlete or have no family history of cancer, it’s probably best to avoid this peptide.
The risk-to-reward ratio isn’t great, and there are better, safer anabolic steroids, drugs, and peptide growth factors available cheaply and easily.
