History and Overview of Pramipexole
Pramipexole Dihydrochloride, also known in the bodybuilding world as Prami, is a dopamine agonist that is very similar to Cabergoline, another compound it works alongside.
The primary reason for using this drug is to treat Parkinson’s disease.
Pramipexole is very commonly found under the brand names Sifrol, Mirapexin, and Mirapex. While some generic versions of this drug exist, these three are typically the main ones used.
Mirapex is known under the brand name of the pharmaceutical company Boehringer Ingelheim.
Along with treating Parkinson’s disease, Pramipexole is also prescribed to treat patients with Restless Legs Syndrome.
It is a drug that has shown a lot of promising signs, especially in treating bipolar disorder, but many do not give it this label at all.
Function and Action of Pramipexole
Pramipexole is a dopamine agonist that directly interacts with the prolactin hormone.
When dopamine levels in the body increase, prolactin decreases.
It can perform this action chemically because it directly interacts with the dopamine D3 receptor.
It is also important to note that it works with the D2 receptor and has an affinity for the D3 receptor that is about 7 times stronger than other existing dopamine agonists.
Considering the availability and strength of Pramipexole, its effects are not at all surprising.
Not only does Pramipexole have a very profound effect on the D3 receptor, but it also has a powerful impact on the nervous system.
That is why it is very effective in treating Parkinson’s disease and, in some cases, is also used to treat Alzheimer’s disease.
Because it acts on the D3 receptor, it can enhance a man’s sexual interest and drive.
Prolactin has a very significant impact on why a man’s sex drive may not be strong, and sometimes when it gets too high, it can cause serious sexual problems.
Therefore, when a man takes Pramipexole, his dopamine levels can rise, leading to improved sexual interest and function.
Additionally, Pramipexole reduces the time between sexual encounters, making the desire for rest or recovery less prominent.
Effects of Pramipexole
The medically positive effects of Pramipexole are particularly related to the symptoms of Parkinson’s disease.
First of all, Pramipexole can improve a person’s mood.
It is also used by many athletes to treat gynecomastia and improve sexual function affected by certain types of anabolic compounds, but in most cases, it is used to treat gynecomastia.
Specifically, Nandrolone-based drugs and Tren (though most serious athletes wouldn’t think of touching Tren) can be treated using Pramipexole or a similar dopamine agonist.
When prolactin levels rise sharply, along with increased estrogen levels, it can lead to gynecomastia, the development of male breast tissue.
Even if estrogen levels are not high, for men who are sensitive to gynecomastia, prolactin can still cause the formation of breast tissue.
That is why it is important to take a dopamine agonist like Prami or its sister drug, Cabergoline, as gynecomastia can still be an issue if steps are not taken to lower prolactin levels.
However, not all men will have problems with prolactin increases from steroids, so you might use a Nandrolone-based drug like Deca Durabolin and not experience any prolactin-related issues.
That said, this can be very dependent on the individual, in addition to the dosage of the substance being used.
But men who take Pramipexole can gain an extra level of control.
When prolactin levels get high, a man’s sexual function, especially related to erections, can be significantly diminished.
Nandrolone is very notorious for inhibiting erections, causing erectile dysfunction, and many men are wary of taking this drug for this reason alone.
In most cases, they will avoid it altogether, and this is completely understandable.
That said, the reason these problems occur is related to the rise in prolactin.
By taking a small amount of Pramipexole, these adverse issues can be avoided, and you don’t even need to take a huge amount.
With the right hormones and a little Pramipexole, all these problems can disappear, allowing the drug to continue working without adverse side effects.
Pramipexole can also increase serum growth hormone levels.
While not by a large percentage, for some men, a slight increase can be very beneficial for several reasons and can lead to much better recovery and deeper sleep.
However, this increase is very short-lived and typically only lasts for a few hours after the initial dose.
Side Effects of Pramipexole
When it comes to side effects, there aren’t many that are uncontrollable; most are related to the individual genetic traits of the person taking it.
These include nausea, upset stomach, headaches, insomnia, muscle cramps, and general weakness.
In most cases, these issues can be avoided as long as you don’t take too much of the drug.
When taking this dopamine agonist, you should always keep the dosage as low as possible to be safe.
The most common of the side effects listed above is nausea.
This occurs when prolactin is suppressed too much, and feelings of discomfort and illness begin.
This will go away with time, but it’s not a good feeling at all and should be avoided.
Even small doses can cause these symptoms in some individuals, so Cabergoline should be the first option for prolactin control.
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Pramipexole Administration
Pramipexole is typically taken orally in strengths ranging from 0.25mg up to 1.5mg.
It comes in the form of oral tablets.
Dosages for Parkinson’s disease are higher than for other conditions, typically starting at 0.125mg a few times a day and increasing up to 1.5mg two to three times per day.
If you’re using the drug to prevent gynecomastia and other symptoms related to prolactin, or for sexual function, 0.25-0.5mg twice a week is exactly what you need.
Always start with a low dose and increase it if necessary.
Conclusion
Overall, Pramipexole is an excellent option as a dopamine agonist for prolactin control.
However, due to the gastrointestinal issues associated with Pramipexole, many people prefer to control their prolactin with Cabergoline instead, but it remains a potent option for managing prolactin levels.
Some people do not tolerate Pramipexole well, which is why Cabergoline is sometimes the next best choice.
Using an aromatase inhibitor (AI) like Arimidex or Aromasin also helps control prolactin through a long feedback mechanism.
